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Topic: "Migraine" and treatment and prevention with "anti-CGRP drug"

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"Migraine" and treatment and prevention with "anti-CGRP drug"





Migraine Believe that many people will hear this name Or some people may be suffering from this disease Migraine, a chronic neurological disease, is found in up to 20% of the population, with women two to three times more at risk than men.


Migraine risk factors



Not getting enough rest


Temperature changes


Eating foods containing tyramine, such as cheese, yogurt, caffeinated beverages, or alcohol.


Female hormone levels during menstruation When I have a migraine. Will cause severe headaches, often on one side, throbbing pain and rhythm with nausea - vomiting.


Increased sensitivity to external stimuli Especially bright light, noisy or a pungent smell, sometimes it can be so severe that the need to stop work and bed rest.


CGRP and Migraine Treatment

Nowadays, CGRP is a neuropeptide in the body. This causes blood vessels in the brain to expand and stimulate pain through nerves. CGRP is higher in people with slot migraine. Therefore, the injection of CGRP inhibitors is one of the options for migraine patients. This makes it possible to prevent and control migraine headaches effectively and safely.



"Migraine" focuses on prevention rather than just treatment.

Lieutenant Colonel Keeratikon Vongvaiwanich Brain and Neurologist, Bangkok International Hospital, said that when a headache occurs We often find pain relievers to take. These drugs are used to treat acute pain such as non-steroidal anti-inflammatory drugs (NSAIDs), triptans, and ergotamine. Is that migraine Some people may have frequent headaches almost every day. In addition, taking pain relievers often won't go away. Resulting in reduced work efficiency Inability to socialize or work normally Including deteriorating quality of life




Therefore, preventive treatment is important in patients with migraine headache. Especially in people who have frequent headaches Severe pain Does not respond to oral pain medication Or have contraindications or have side effects from the use of painkillers



Current anti-migraine medications May not be directly treated

Today's oral anti-migraine medications, such as anticonvulsants, antidepressants, pressure reducing drugs, are not intended to treat and prevent migraines. But it can be used to reduce the frequency and severity of migraines. Discovery of Calcitonin Gene-related Peptide or CGRP, a neuropeptide in the body. Act on the mechanism of pain receiving through the cranial nerves. Especially the fifth cranial nerve, which is the main nerve in the head, neck and face.


CGRP also has effects on the brain's blood vessels to expand. In people who suffer from acute migraine headaches, they have higher levels of CGRP in their blood than normal people. The discovery of CGRP led to the development of drugs to inhibit CGRP.At present, there are two major groups of drugs that inhibit CGRP: CGRP monoclonal antibody and CGRP receptor antagonist.


From studies in people It was found that CGRP monoclonal antibody drugs reduced the number of days of migraine pain. And reduce the amount of pain medication used It also increases the quality of life for people with migraine as well. Studies in patients with difficult-to-treat migraine such as chronic migraine, migraine unresponsive to other preventive medications (prior preventive treatment failure), and medication overuse headache) responds better to CGRP monoclonal antibody drugs than other oral preventive drugs, which are injected under the skin, with the advantage of each injection. It has a protective effect for about 1 month, thus reducing the problem of forgetting to take the drug. And there are clearly fewer drug side effects than other anti-migraine drugs.


Side effects were more common than placebo, such as pain or redness at the injection site. Upper respiratory infection and constipation which are mild side effects In terms of long-term safety By following up to 3-5 years of drug use, CGRP monoclonal antibody was found to be highly safe for the cardiovascular system. Blood pressure and heart rate did not change. As well as does not affect liver function



In summary, migraine headache is a serious disease. It affects both the body, mind and society as well as the quality of life. Preventive therapy can reduce the severity of the disease. CGRP monoclonal antibody drugs are effective specifically against migraine headaches. Especially in patients with chronic migraine or not responding to other preventive medications. And there are long-term studies confirming the effectiveness of the treatment and safety.

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